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Preclinical studies identified several mechanistic pathways through which curcumin may alleviate DACD, including anti-inflammatory and antioxidant effects via NF-B, NLRP3, AKAP150/PKA/PP2B, miR-146a-5p/ERK, BDNF/TrkB, ROS-ERK1/2, GABA receptors, Keap1-Nrf2-ARE, and regulation of intestinal flora

Other next-generation agents, such as IPN60090 (IACS-6274), have demonstrated early signs of clinical activity and effective GLS1 inhibition in Phase I studies, with ongoing trials exploring combinations (e.g., with bevacizumab and paclitaxel)

Statistical Analysis Statistical analysis was performed using Statistica 7.0

To add to the complexity, some forms of mercury convert in vivo from inorganic to organic

O'Neill in 1962 to measure the heat flow of solid materials and determine phase transitions, melting, crystallization, and heat capacity (Watson and O'Neill, 1962), whereas in 1964, Peter L