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When exposed to LPS and IFN-, macrophages are polarized into the M1 phenotype, accompanied by enhanced glycolysis, increased lactic acid production, and activation of the pentose phosphate pathway (PPP)

While iron is essential for brain function, it is toxic to neurons at high concentrations (60)

Um, I remember Bernie Sanders saying like, if this drug gets as much traction as it needs to, it will bankrupt Medicaid

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Further, mast cells are one of the fastest responders by releasing prestored and newly synthesized mediators among immune and inflammatory cells (Bulfone-Paus et al., 2014