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During the summer months, the UV radiation produces more and more melanin, which lowers the natural glutathione of the body and makes the results less effective

But topical application has inherent limitations

Animal studies also tout promising results with acetyl-L-carnitine supplementation

"Familial deficiency of glutathione reductase in human blood cells"

The drug hydroxyurea (Hydrea), which is often used to treat painful crises in sickle cell anemia, may be of benefit in some thalassemia patients (Rund 2005)