6 Pharmacological and surgical interventions to improve cognitive impairment in diabetes At present, several potential therapeutic approaches are available to prevent and ameliorate cognitive impairments in diabetic patients
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[Choline deficiency studies - see full reference list] 73-75
The convergence of shortened telomeres and unrepaired DNA lesions triggers the senescence-associated secretory phenotype (SASP), through which granulosa cells secrete inflammatory cytokines (IL6, IL8, TNF-), matrix metalloproteinases (MMP1, MMP3), and growth factors (VEGF, FGF2) [185, 200,201,202,203,204]