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Behavioral interventions were more effective when they provided more intensive counseling, were augmented with messages and self-help materials tailored for pregnant persons, and included messages about the effects of smoking on both maternal and fetal health and strong advice to quit as soon as possible

These receptors control the release of noradrenaline, endogenous opioids, dopamine, and other neurotransmitters that activate the descending pain modulatory pathway or suppress the nociceptive input to the spinal dorsal horn [7, 8]

Surgeon Generals landmark report on smoking was published (87)(88)

They can and should be part of a healthy diet

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