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This work represents one of the first demonstrations of FOXO4-DRI activity in primary human cells, supporting translational relevance beyond the initial mouse model findings

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Importantly, we detected a strong trend for increased abundance of cleaved caspase 3-positive cells in eWAT of obese IF mice (Fig

[362] noted a decline reduction in high baseline ERG amplitudes with high-dose vitamin A supplementation, although these results were not replicated in larger randomized studies [363]