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Potential applications include treating neurological conditions

de Rus JA, Alpaugh M, Denis HL, Tancredi JL, Boutin M, Decaestecker J, et al

Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with P13K inhibition or demethylating agents

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The absence of verified pharmacokinetics and product verification prevents evidence-based recommendations regarding discontinuation timing, perioperative safety, and postoperative resumption, leaving surgeons unable to quantify risk in elective operative settings