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This is the window that the Finkley 2005 trial captured, and the Carey/Pickart ultrasound work confirmed at the structural level: an average 28% increase in collagen density, with top responders at 51%

Safety and Efficacy of Intravenous Ultra-high Dose Methylcobalamin Treatment for Peripheral Neuropathy: A Phase I/II Open Label Clinical Trial

Patients with dissection (n = 125) had significantly increased values of ICA tortuosity compared to healthy controls (n = 24) (OR 2.65[CI 1.68-3.86], p 100 mmHg) at randomization

What is the status of platelet derived preparations (e.g PRP and PRF)

Not always, but labs can help when symptoms point to anemia, thyroid shifts, low vitamin D, or hormone shifts