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Dysbiosis, characterized by a reduction in beneficial microbes and an overgrowth of pathogenic bacteria, is commonly observed in IBD patients

The combination of GPX4 inhibitors with immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis increases the proportion of CD8 + T cells, enhances their cytotoxic activity and induces ferroptosis, thereby promoting chemotherapy resistance [42]

By preventing nicotinamide methylation, the compound increases intracellular NAD+ availability, which in turn activates sirtuins and other NAD+-dependent enzymes critical for metabolic homeostasis

This ensures the needle reaches the muscle tissue effectively