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[DOI] [PubMed] [Google Scholar] 48.Chen Y., Wang W., Wang H., Li Y., Shi M., Li H., Yan J

The usual approach includes a loading dose followed by regular maintenance therapy

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5-Alpha Reductase Inhibitors (5-ARIs) (Examples: Finasteride, Dutasteride ) Action: Shrink the prostate over time by lowering DHT Onset: Slower 6 to 12 months Efficacy: Shrinks prostate by ~ 2025% Reduces risk of surgery or retention by ~50% (MTOPS trial) Side Effects: Decreased libido Erectile dysfunction Rare: breast tenderness or depression 3

Tetrahydrofolic acid, methyltetrahydrofolate, and other folic acid congeners are essential for the maintenance of normal erythropoiesis and are also required cofactors for the synthesis of purine and thymidylate nucleic acids