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At 20 M, 10-gingerol, 6-shogaol, 8-shogaol, and 10-shogaol reduced the secretion of IL-1 on LPS-primed and ATP-activated IL-1 secretion in THP-1 macrophages with the inhibitory values of 102.2, 95.2, 63.6, and 46.5%, respectively (Ho & Chang, 2018)

Reported reactions included nausea, vomiting, chills, low blood pressure, breathing difficulty and hospitalization, with excessive endotoxin exposure identified as a concern

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