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These cells contribute to the permeability and integrity of the BBB through their intimate anatomical relationship (Liebner et al., Every constituent cell of the NVU contributes to the BBBs integrity, and any dysfunction might result in the barrier breakdown, with dramatic consequences such as neuroinflammation and neurodegeneration (Kempuraj et al., 2019)

In addition to aiding weight loss, semaglutide 2.4 mg also enhances eating regulation, lessens food cravings, and lessens the typical rise in appetite that follows substantial weight loss, all of which support continued weight control [112]