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In some embodiments, the otic formulation or composition comprises between about 1% to about 5% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

doi:10.1007/3418_004

This inherent protective quality is not confined to a single organ system but rather exerts a stabilizing influence across various tissues, providing the mechanistic foundation for its dual action in both the gastrointestinal tract and the central nervous system

Cotruvo JA Jr, Arona AT, Ramos-Torresa KM, Chang CJ

The higher gastrointestinal adverse-event rate relative to semaglutide is the flip side of the greater weight loss and again points to escalation speed as a lever for tolerability