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It is important to note that when activated, PGC-1 can translocate to the nucleus, where it activates NRF2, thereby initiating the transcription of nuclear-encoded respiratory chain components and mitochondrial transcription factor A (Tfam)

In mammals, this multitasking indolamine is synthesized in the pineal gland in a circadian manner in response to the photoperiodic information received via the retinohypothalamic pathway 4,5

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This reduction may theoretically lessen inflammation and oxidative stress in impacted tissues

Model of the import of precursor proteins into mitochondria and components of the translocation apparatus