A patient with unexplained fatigue should be worked up, not injected masking a B12 deficiency of unclear cause, or an unexamined thyroid problem, with a monthly shot is a real clinical risk
RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition
Cyanocobalamin: usually room temperature Cyanocobalamin is generally stable at controlled room temperature, away from heat and direct sunlight, though you should still check the BNF entry and the product leaflet for the exact storage line
Additional effects include uncoupling of the electron transport chain to produce heat [185, 189]
The right choice depends on deficiency cause, route preference, tolerability, availability, and monitoring needs