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In vitro functional analyses confirmed their mature hepatocyte characteristics: they showed high transcription and protein expression of ALB, A1AT, CYP3A4, and CYP2C9, comparable to primary human hepatocytes (PHs)

Accumulation of amyloid beta induces oxidative stress and inflammation at the neurofibrillary tangle level, inducing neuronal death stimuli in the brain of patients with AD [91,92]

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