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An early publication in the Annals of the New York Academy of Sciences documenting the original discovery of telomere shortening as a primary mechanism of cellular senescence and its relevance to human aging biology provides the foundational framework for understanding why telomerase-activating compounds attract longevity research attention

Peak annotation, motif analysis, and super enhancer analysis were performed with HOMER and ChIPseeker

333,334 Additionally, hypoxia-induced oxidative stress stimulates autophagy by inhibiting mTOR activity

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This review summarizes the importance and necessity of glutamine for tumor cells and nontumor cells in the tumor microenvironment