The compound maintains chemical stability under pH conditions ranging from 4.5 to 9.2, making it versatile for diverse manufacturing environments
The quality of a research compound depends not only on purity specifications but also on manufacturing controls, testing standards, and traceability
Cobalamins circulate bound to serum proteins called transcobalamins (TC) and haptocorrins
Inadequate secretion of intrinsic factor, resulting from lesions that destroy the gastric mucosa (which can be caused by ingestion of corrosives, extensive tumors, and conditions associated with gastric atrophy, such as multiple sclerosis, certain endocrine disorders, iron deficiency, and subtotal gastrectomy) Structural lesions leading to vitamin B 12 deficiency, including regional ileitis, ileal reactions, and malignancies Competition for vitamin B 12 by intestinal parasites or bacteria
Vitamin B12 deficiency results in megaloblastic anemia, GI lesions, and neurologic damage (which begins with an inability to produce myelin and is followed by gradual degeneration of the axon and nerve head)