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As a typical damage-associated molecular pattern (DAMP) molecule, HMGB1 can mediate heat stress-induced NLRP3 inflammasome activation via the TLR4 and receptor for advanced glycation end products (RAGE) signaling pathways, thereby promoting IL-1 activation and inducing hepatocyte pyroptosis, ultimately leading to severe liver injury in rats [26]
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Zhang HM, Li ZY, Dai ZT, Wang J, Li LW, Zong QB
TB-500: Notch Signaling Angiogenesis & Differentiation Studies suggest TB-500 promotes angiogenesis likely through the Notch signaling pathway, which regulates cell fate decisions and vascular development[5]