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In addition, neuroimaging studies of patients with ADHD reported an elevated level of striatal dopamine transporter activity, which is reverted by the administration of methylphenidate [59, 60]

GPX4 serves a central role in inhibiting ferroptosis by reducing lipid peroxidation and preserving cell membrane integrity

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CMS121 was shown to improve memory, and cognitive function in APPswe/PS1 E9 double transgenic mice ( LOX inhibitors 5-Lipoxygenase (5LO) is widely expressed in central nervous system neurons, and its levels increase in an age-dependent manner in the hippocampus and cortex, two brain regions prone to neurodegenerative damage

doi: 10.1039/C4RA13557A 6