(9) might fail to identify some protease targets, because their high affinity interactions are mostly limited to an 810 residue sequence, and in some cases may be unable to withstand the conditions needed to be isolable and observable by mass spectrometry
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Li S, Li Q, Li Y, Li L, Tian H, Sun X
In Health, an industry where there is massive opportunity to use AI to deliver better real-world, life-changing outcomes, it was not surprising that our teams focused on agentic solutions that: Help clinicians make faster, safer, evidence-informed decisions Distill complex medical research into clear, actionable insights Improve the patient experience through more personalized, human-centered support In watching this event over the years, and seeing our final Tournament of Champions presentations, one thing is abundantly clear to me: many of our most impactful innovations have come from Wolters Kluwer teammates who blend their curiosity, hard work, diverse perspective, collaboration, and sheer grit with their unwavering commitment to making the world a better place
These findings are also interesting from an IGF-1R targeting point of view because pharmacological modulations leading to an excess of MDM2 could be a manner to cause a selective IGF-1 inhibition and apoptosis in cancer cells
