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The hallmarks of cellular senescence, e.g., the appearance of senescence-associated -galactosidase (SA--gal) and heterochromatin foci (SAHF) as well as the increased expression of cell cycle inhibitor proteins, i.e., p16, p21, and p53, are also common markers of senescent immune cells, especially in Teff cells [154,155,156]

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Our approach has always been grounded in the same philosophy that Sanjiv Lal expressed in GQ: the debate is not about whether peptides work, it is about ensuring that the ones we use have sufficient evidence and regulatory oversight