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The link between plasma testosterone or androstenedione and ROS production suggests this

During early development, the NP contains a relatively large amount of cells and a small amount of extracellular matrix (ECM), whereas the ECM/cell ratio is high in the mature NP [3, 4]

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Mechanistic studies further confirm that SCFAs enhance intestinal barrier function ( Zinc intestinal barrier anti-inflammatory pathway: human RCTs (252) demonstrate that zinc supplementation (20 mg/day) upregulates the expression of intestinal tight junction proteins (e.g., occludin) and reduces systemic inflammation