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That accumulation occurs thanks to 2 pathways: the first is the poor or null elimination of that metal by the biliary tract, which causes an elevated serum concentration, and the second is portal hypertension and the creation of collateral circulation, favored by the disruption of the blood-brain barrier, as the pathway of propagation to the brain

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However, the bone-protective effects of these agents remain largely inferential and are not yet supported by robust longitudinal data on BMD or fracture outcomes in human populations

Tyrosinase plays an important role in the formation of melanin in hair

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