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This age-related decline in oocyte quantity and quality leads to reduced fertilization rates, impaired embryo development, and suboptimal pregnancy outcomes in assisted reproductive technologies (ART), particularly in vitro fertilization (IVF) [7, 8]
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They are inactive and require conversion to the native forms, and are not nearly as effective
These locally regulated growth factors and hormones collectively underscore that the follicle functions as a partially autonomous endocrine microenvironment [249]
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