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A phase II study of efficacy and safety of the MEK inhibitor tunlametinib in patients with advanced NRAS-mutant melanoma

Future research will show whether all redoxin inhibitors, including the recently described very specific Prx3 [215] or yet-to-be-developed specific Grx inhibitors, induce ferroptosis

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NRF2 INDUCERS ARE EFFECTIVE FOR CANCER CHEMOPREVENTION Because Nrf2 activates many genes encoding detoxification enzymes, Nrf2 deficiency exacerbates the formation of DNA adducts, which increases the risk of carcinogenesis