Since mouse microbiome profiles often highly correlate with body weight and fat composition, this study was designed to test whether the cecal microbiomes of DIO mice treated with NNMTi and LD were comparable to the microbiomes of age-matched lean counterparts and distinct from microbiomes of DIO mice maintained on a high-fat Western diet (WD) or subjected to LD switch alone
These models could further be leveraged to investigate if NSC-secreted factors modulate the gut microbiomes metabolic output or vice versa, providing a mechanistic link between the central and peripheral effects observed in our study
Stable gastric pentadecapeptide BPC 157 as therapy after surgical detachment of the quadriceps muscle for muscle-to-bone reattachment in rats2025Musculoskeletal BPC 157 promoted quadriceps muscle-to-bone reattachment after surgical detachment in rats, with consistent healing confirmed via ultrasonic, MRI, biomechanical, and functional assessments
Zou Z, Li L, Schfer N, Huang Q, Maegele M, Gu Z
A thin, polymer-based film embedded with peptide is placed on the sublingual tissue, where it adheres and dissolves over 2 to 5 minutes
