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Healing depends on basic requirements: oxygen, amino acids, micronutrients, immune signaling, and mechanical loading that is appropriate for tissue remodeling

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doi: 10.1038/nm.3882 27

BBB dysfunction was not apparent in patients with anosmia without accompanying brain fog implying this might not be a major driver of this symptom

This response is dynamic and depends on the exposure of the organism to exogenous substances, as well as the microbial components, metabolites, and local microenvironment