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You can observe lethargy, weak muscles, tiredness or thinning of coat in dogs

Patients in the third month of their protocol often describe the change not just as less pain but as a qualitative shift in how the injured area functions by month three: more fluid movement, faster recovery, and less restriction than before the protocol started

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MOTS-c modulates the FOXO transcription factors and regulates cellular senescence, the state in which aged or damaged cells stop dividing but refuse to die, instead secreting a cocktail of inflammatory signals known as the senescence-associated secretory phenotype (SASP)

BMJ open 10 (8), e033687