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Several molecular mechanisms have been identified that may explain resistance and increased invasion after anti-angiogenic therapy in glioma, including mesenchymal transition of tumor cells, up-regulation of pro-angiogenic factors, activation of MET and up-regulation of MMPs [293,294,295,296]
The progression of pernicious anaemia is typically slow and may be challenging to recognise due to the gradual development of symptoms
Budd-Chiari syndromehepatic venous outflow tract obstruction from any cause Etiology The main predisposing causes of BCS include a hypercoagulable state, tumor invasion of the hepatic venous outflow tract, and miscellaneous causes