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A meta-analysis of 12 clinical trials measuring flow-mediated vasodilation (FMD
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Hypoxia affects cerebrospinal fluid circulation and clearance, resulting in cerebrospinal fluid retention, induces the release of proinflammatory cytokines (e.g., TNF-, IL-1, IL-6), activates microglia, intensifies brain tissue damage, and increases the generation of reactive oxygen species (ROS) which damage neurons and the vascular endothelium ( 3 Progress in research on TCM-based treatment of HACE 3.1 Understanding of HACE in TCM TCM is guided by a holistic view that considers human health dependent on the dynamic coordination between the internal and external environments
