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The gut microbiota metabolite capsiate regulate SLC2A1 expression by targeting HIF-1 to inhibit knee osteoarthritis-induced ferroptosis

These results indicate that inhibition of neuronal excitotoxicity can alleviate neuronal necrosis to a certain extent

Lactobacillus helps repair the intestinal epithelial barrier by upregulating tight junction proteins and reduces colonic inflammation in UC mice by inhibiting the TLR4-NF-B-NLRP3 signaling pathway [42, 43]

Some drugs also use a lot of heme iron, which reduces iron and oxygen for other organs, possibly causing tissue damage and increasing harmful molecules

(DeCampo and Moreno, 1984