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In vivo , treatment with AST alleviated motor impairments and mitigated the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) of C57BL/6J mice

While research on the relationship between ferroptosis and OA is limited, emerging evidence suggests that ferroptosis plays a crucial role in regulating chondrocyte activity, extracellular matrix degradation, and synovial inflammation, thereby influencing OA progression (Feng et al., 2020

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Two transcription factors that form an integral part of the pathways augmented during this transition period are HIF-1 and NF-B, both of which are sufficiently tuned to govern a specific response in hypoxia and a relatively hyperoxic shift [184191]

Acknowledgements The authors acknowledge Dr