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doi: 10.1093/infdis/jiv103 13 AttoB.EapenM

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A tailored DNA nanoplatform for synergistic RNAi-/chemotherapy of multidrug-resistant tumors

Histidine is a unique amino acid with respect to its interactions with copper

This led to the discovery of NP-BTA, a N-pyridinyl--thienyl-acrylamide derivative, was discovered to inhibit the essential enzyme glutaminyl-tRNA synthetase (Gln4), representing a novel antifungal mechanism of action (Fu et al., 2021)