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[114] The FDA concluded in 2020 that kava is not generally recognized as safe (GRAS) for use in conventional foods due to evidence of toxicity, potential liver damage, possible carcinogenicity, drug interactions, and a lack of sufficient safety data

[DOI] [PMC free article] [PubMed] [Google Scholar] 133.Mukherjee R., Nunes Q., Huang W., Sutton R

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The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator