Yes, but the dose required is 35 higher than sublingual or intranasal routes to achieve comparable plasma concentrations
For instance, nanoparticle-based inhalers have been shown to increase lung deposition of medications by up to 3.68 times more compared to traditional inhalers, potentially revolutionizing the treatment of conditions like cystic fibrosis and severe asthma
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However, no significant difference was recorded in serum levels of bicarbonate, sodium, uric acid, or total protein in the treated group (TG) compared with the positive control (PC) ( Figure 1 )
30-60 minutes: The average onset time for both medications to start working