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Thus, cholinergic neurotransmission and ACh-dependent regulation of non-neuronal cells employ ThDP coenzyme function for ACh synthesis and non-coenzyme action of thiamine in ACh signaling

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Therefore, a multiple standard addition approach was employed for method validation, enabling accurate quantification despite significant matrix effects without requiring isotope-labeled IS

A candidate for a potential glutathione-scaffold residue was identified using the following selection criteria: The residue should be rather conserved in enzymatically active in contrast to inactive glutaredoxins and have a charged side chain to ensure a strong ionic glutathione interaction (Fig

Identifying these triggers is part of the "Live with Intention" approach, as it allows us to address the root causes of depletion before reaching for a bottle