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It has been previously suggested that the accumulation of GSSG may exert cytotoxic effects due to its propensity to form disulfides with intracellular proteins, which leads to their inactivation (Forman et al., 2009

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However, when very high oral doses are taken, approximately 1% can be absorbed through passive diffusion, independent of intrinsic factor, which explains how mega-doses can still raise serum levels