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In diet-induced obesity (DIO) models, NNMT loss-of-function and selective small-molecule inhibitors reduce white adipose mass and improve metabolic parameters without overt toxicity, positioning NNMT as a tractable target for metabolic-disease research [24]

For short-term use, refrigeration at approximately 4C (39F) is suitable

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Reported side effects are generally mild and include temporary gastrointestinal discomfort, headaches during initial use, occasional fatigue as the body adjusts, and rare nausea, especially when taken without food