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Differential methylation, particularly in relation to active demethylation pathways, and expression patterns of genes regulating lipid metabolism, inflammation, and fibrosis appear to be closely linked to the development and exacerbation of MASLD, from steatosis to more severe forms such as MASH and fibrosis [335, 336]
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In H 2 O 2- induced PIG1 oxidative stress model of normal human epidermal melanocytes, paeonol inhibited hydrogen peroxide induced decrease in cell viability in a dose-dependent manner
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