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Once the stopper loses vacuum seal (no audible hiss on first puncture), air exchange is occurring refrigeration alone cannot compensate for oxidation at that stage.

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The reduction in AUC after oral administration can result from numerous mechanisms including: pH or bacterial-mediated metabolism of the drug within the GI tract, incomplete drug absorption from the GI tract, metabolism within the GI epithelium (which contains CYP3A4), excretion back into the GI tract by P-glycoprotein in the GI epithelium, hepatic metabolism, or biliary excretion into the GI tract

For long-term handling protocols, see our peptide storage guide

In some embodiments, the otic pharmaceutical formulation comprises about 86% by weight of the triglycerides