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2002;23 Suppl 3:11144

In agreement, ATF4 knockdown significantly decreased GSH level in these cells (Fig

Extensive experimental and computational studies have shown that the binding of GSH to GSTs decreases the p K a of the GSH thiol group from around 9 to about 6 in the active site through hydrogen bonding and salt bridges and through the positive electrostatic potential of the G-site 41,42