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Such reduced risk products, if backed by robust scientific evidence, have the potential to meaningfully impact public health by providing smokers an alternative way to satisfy their nicotine craving with less risk

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This approach allowed us to systematically identify all relevant studies indexed in PubMed up to 31 May 2022, and we extracted relevant data on risk of smoking, including study characteristics, following a pre-specified template (Supplementary Table 2)

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