Chronic insulin treatment causes insulin resistance in 3T3-L1 adipocytes through oxidative stress
Photo Credit: English: NPS, Public domain, via Wikimedia Commons Credit Above Photo: Fort Union Trading Post National Historic Site, Public domain, via NPS
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due to unregulated proliferative of retinal pigment epithelial and glial cells, manifesting as starfolds, retinal contraction, retinal folds, or preretinal fibrosis), intraretinal cysts, retinal macrocysts, pigmented demarcation lines (reflecting RPE cells at the edge of slowly advancing subretinal fluid), and high intraocular pressure (due to Schwartz Matsuo syndrome where RPE cells block the trabecular meshwork)