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It was also reported in DRG neurons of wild type and TRPV4 knockout mice that activation of TRPV4 by paclitaxel induced mechanical allodynia and excessive ROS production, although the allodynia and oxidative stress was partially decreased by the TRPV4 antagonist treatment (Materazzi et al., 2012) (Table 1)

signs and symptoms include anorexia, anxiety, irritability, depression, anhedonia, decreased social communication and environmental interest, cognitive changes, including decreased concentration, learning ability and memory

38 : e23

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KPV appears to exert its effects via the peptide transporter PepT1 rather than classical melanocortin receptors