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383,384 Once IL-6 binds to IL-6R, the IL-6/IL-6R complex is able to activate its coreceptor gp130, which initiates downstream pathways, including the JAK/STAT3, PI3K/AKT, and MAPK pathways

Organ meats such as liver and heart are the richest source of bioavailable B12 (16)

doi: 10.1113/jp277336 17 BuonocoreS.AhernP

Additionally, for patients with DILI specifically affecting liver cells (hepatocellular DILI), progressively worsening jaundice should also raise concerns and prompt evaluation for a potential liver transplant by a specialized center [130]