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Unfortunately, due to its high cytotoxicity, aminoguanidine cannot be used in clinical practice 83

Given that fluoropyrimidine-based therapy will remain a major treatment modality for patients with advanced CRC for the foreseeable future, the need for better, more effective chemotherapy combinations in biologically selected populations to overcome drug resistance is an urgent, unmet need for patients with CRC worldwide

While the molecular ruthenium catalyst and the nanoreactors without carbon fluorinated moieties were cytotoxic in the low micromolar range in a 21% O 2 atmosphere, these compounds lost their therapeutic effect in a 1% O 2 atmosphere

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Vitamins, especially vitamins like B12, are an important part of maintaining our inner balance