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120 In myeloid cell-specific SIRT1 knockout mice, lipid toxicity or LPS stimulation induced more severe hepatic inflammation, elevated pro-inflammatory cytokine levels, and enhanced M1 macrophage polarization, highlighting the critical role of SIRT1 in preserving immune balance

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[5] Safety Profile and Known Risks The safety question around BPC-157 has two distinct dimensions: what the existing data shows, and what it cannot yet rule out