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We speculate that PUFAs and iron are specifically absorbed in the small intestine 32,33,44 , which could be one explanation for small intestinal disease localization and a requirement for GPX4 activity in the small intestine

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2,2-Di-pyridylketone hydrazone dithiocarbamate s-butyric acid (DpdtbA), an iron chelator, exhibited potent antitumor effects in gastric and esophageal cancer cells

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