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It was concluded that, in comparison with controls, patients with ME/CFS have a higher resting heart rate, lower maximal/peak heart rate, higher heart rate responses to head-up tilt testing and moving from sitting to standing, and a lower heart rate at submaximal exercise threshold

The question of whether a serum "works topically" is largely a function of whether its molecules ever cross the skin barrier

My tone became brighter, smoother and more-even